BBSRC Portfolio Analyser
Award details
Virulence Determinants in Rinderpest Virus
Reference
BBS/E/I/00001012
Principal Investigator / Supervisor
Professor Thomas Barrett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
536,343
Status
Completed
Type
Institute Project
Start date
01/04/2003
End date
31/03/2008
Duration
60 months
Abstract
Revere genetics for RPV was developed some years ago in the Pirbright laboratory and is also the only way at present that virulence factors of RPV can be studied at the molecular level. In this project genomes from strains of different virulence will be sequenced in their entirety and assembled into full-length cDNAs for virus rescue. This approach has been successfully applied to identify attenuating mutations in the vaccine strain of RPV, which were found to be present in several of the structural protein genes and in the virus promoters. Variations that might explain pathogenic differences between field viruses can be identified in a similar way and these motifs/genes exchanged between the strains and their effects on virus pathogenicity determined experimentally in cattle. This will give an insight of how natural variation in the field affects virus virulence, which most probably will be different from the multiple mutations that have accumulated in the vaccine virus, and allow better predictions to be made on the likelihood of field reversion of mild to virulent forms.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search