Award details

Classical swine fever immunopathogenesis

Reference	BBS/E/I/00001006
Principal Investigator / Supervisor	Professor Bryan Charleston
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	23,550
Status	Completed
Type	Institute Project
Start date	01/04/2003
End date	31/03/2006
Duration	36 months

Abstract

The principal objective of this project is to determine how CSFV modulates the normal processes whereby the host limits infection. These mechanisms invariably involve innate immune responses resulting in an interferon induced anti-viral state and/or apoptosis of infected cells. Viruses that survive these innate responses are cleared by the effector cells of the acquired immune response for example cytotoxic T-cells. Our previous work has shown that CSFV blocks both production of interferons and apoptosis through mechansms that involve synthesis of viral proteins. We will now expand this research to study precisely where the virus blocks these important cellular pathways and which viral proteins are involved. We will also study the effects of CSFV on molecules released by cytotoxic T-cells that trigger apoptosis. It is clear that an understanding of the mechanisms whereby innate and aquired immune responses to CSFV are blocked are provides key information for understanding the molecular basis of virulence of CSFV.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search