Award details

African swine fever immune evasion genes

Reference	BBS/E/I/00001003
Principal Investigator / Supervisor	Dr Linda Dixon
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	25,493
Status	Completed
Type	Institute Project
Start date	01/07/2003
End date	30/06/2006
Duration	36 months

Abstract

The main objective is to gain a better understanding of how African swine fever virus manipulates macrophage function and of the role played by specific ASFV encoded proteins in evasion of host defence systems. We will compare the effect of ASFV isolates of different pathogenicity on macrophage gene expression using a porcine cDNA microarray containing 2000 genes. We will also determine the effect of two ASFV proteins, A238L and CD2v, on macrophage gene expression using this cDNA microarray. These two proteins have an important role in evading host defence systems. They function by interacting with host signalling pathways, thus potentially affecting the expression of a wide range of host immunomodulatory genes. ASFV is predicted to encode many proteins involved in evasion of host defence systems and we will also identify novel viral immune evasion proteins. The benefits from the work will be a better understanding of virus host interactions. This will lead to a better understanding of both the mechanisms used by the virus to evade host defence systems and thus persist in its host and of the mechanisms of virus pathogenesis. The results may also help to identify host resistance mechanisms. This knowledge will aid in the development of an effective vaccine against ASFV and improve our understanding of the characteristics of isolates of varying pathogenicity. The results will be made available to the scientific community by publication in refereed journals and presentation at meetings. Knoweldge and reagents from this project will help to direct work on ASFV and on other pathogens

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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