Award details

ImmunoTSE

Reference	BBS/E/I/00000989
Principal Investigator / Supervisor	Professor Neil Mabbott
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	40,320
Status	Completed
Type	Institute Project
Start date	01/11/2002
End date	30/04/2006
Duration	42 months

Abstract

The aim of the proposal is to identify potential therapeutic targets at the pre-clinical stages of transmissible spongiform encephalopathies (TSE). Studies will demonstrate and characterise the roles of dendritic cells (DCs) in the propagation of TSE agents (prions) to the nervous system. DCs are involved at multiple levels of the infectious process, and their properties and functions might be manipulated. The following steps will be analysed: 1. Penetration through the gut epithelium 2. Accumulation in the mucosa-associated lymphoid tissue 3. Spreading to other lymphoid organs 4. Factors of prion propagation (complement, chemokines and receptors) 5. Spreading from lymphoid structures to the nervous system. The in vivo research may not be performed on naturally infected subjects, and must use a relevant experimental model, i.e. a standard oral inoculation protocol with well-defined mouse experimental scrapie strains. Finally, certain studies will require in vitro analyses, especially those aimed at identifying molecular interactions.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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