Award details

The nature of CD8 T-cell memory in bovine tuberculosis

Reference	BBS/E/I/00000987
Principal Investigator / Supervisor	Professor Christopher Howard
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,717
Status	Completed
Type	Institute Project
Start date	01/10/2002
End date	30/09/2005
Duration	36 months

Abstract

CD8+ T-cells have been shown, in the murine model, to play a role in protection against TB. Human CD8+ T-cells have been shown capable of killing mycobacteria in antigen presenting cells (APC) . In cattle, following BCG vaccination or M. bovis infection bovine CD8+ T-cells that proliferate and/or produce IFN? in the presence of mycobacteria-infected dendritic cells are evident. However, little is known about the properties and functions of CD8 memory to bacterial infections in humans or other species. Data from human studies of virus infections indicate the presence of sub-populations of antigen primed CD8 T-cells that are either memory, recently activated or effector CD8+ T-cells. While bovine CD4+ memory T-cells have been defined as being CD45RO+, this is not the case for CD8+ T-cells. Memory CD8+ T-cells are found in both CD45RO+ and CD45RO- populations. This appears similar to the findings in humans in which expression of CD45RA in conjunction with the level of expression of CD11a has been used to define memory CD45RO- CD8+ T-cells. Functionally distinct subsets of CD8+ T cells will be defined in cattle vaccinated with BCG or infected with M. bovis to provide an insight into the nature of the CD8 responses and aid development of paradigms for T-cell memory to an intracellular bacterial pathogen.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search