Award details

Characterisation of bovine natural killer (NK) cells and their role in determining immune bias

Reference	BBS/E/I/00000970
Principal Investigator / Supervisor	Professor Jayne Hope
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	85,006
Status	Completed
Type	Institute Project
Start date	01/03/2003
End date	05/08/2006
Duration	41 months

Abstract

Mycobacterium bovis causes bovine tuberculosis and can cause potentially fatal infections in humans as well as having a profound economic impact on cattle herds in infected areas. We have identified a putative NK cell in neonatal calves that proliferates and synthesises IFN-gamma in response to M. bovis-BCG infected dendritic cells. This interaction may be critical for the generation of protective cellular immune responses that need to have the strong Th1 bias necessary for effective immunity against TB. We propose to characterise NK-like cells present in cattle and determine their role in the induction of Th1 biased immune responses. The requirements for stimulation of the cells will be determined and their immunological functions characterised.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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