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Award details
Analysis of chicken TLR7
Reference
BBS/E/I/00000964
Principal Investigator / Supervisor
Dr Adrian Smith
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
2,991
Status
Completed
Type
Institute Project
Start date
01/10/2002
End date
30/09/2005
Duration
36 months
Abstract
Toll-like receptors (TLRs) are a family of transmembrane proteins that play an important role in recognizing microbial pathogens and triggering an appropriate immune response. The aim of this project is to define the role of TLR7, which is one of a pair of tandemly duplicated genes in mammals implicated in the immune response to small anti-viral compounds, in the recognition of chicken microbial pathogens. Large chicken genomic clones containing TLR7 have been isolated and are currently being commercially sequences. The first stage of the project will invovle analysis of the sequence data to determine whether other TLRs lie in the vicinity of TLR7 and to generate tool for further characterisation of these genes. The second stage of the project will be directed at functional analysis with the particular aim of identifying the microbial stimuli necessary to activate signalling of TLR7 and any related genes.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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