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Award details
Optimizing DNA based vaccination against FMDV in sheep and pigs
Reference
BBS/E/I/00000962
Principal Investigator / Supervisor
Dr Paul Barnett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
105,084
Status
Completed
Type
Institute Project
Start date
01/09/2002
End date
31/08/2006
Duration
48 months
Abstract
Our objectives will be to identify the best ways of optimizing the efficacy of DNA vaccines to FMDV in sheep and in pigs. Efficient DNA vaccines to FMDV could replace current inactivated vaccines and emergency vaccines, depending on EU policy of FMDV eradication programmes. As a potential emergency vaccine, the optimized DNA vaccination strategies will be tested for their ability to induce early protective immunity, following preferably only one DNA injection. The various parameters tested will include several FMDV antigens, a new generation of plasmids, promising adjuvants, several routes of administration and homologous (DNA/DNA) versus heterlogous (DNA/protein) prime-boost regimens. Protective immunity will be evaluated in tow major target species for FMD: sheep and pigs.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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