Award details

Development of protection against direct contact challenge following "emergency" FMD vaccination of cattle and effect on virus excretion

Reference	BBS/E/I/00000961
Principal Investigator / Supervisor	Dr Paul Barnett
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	57,307
Status	Completed
Type	Institute Project
Start date	25/11/2002
End date	24/11/2006
Duration	48 months

Abstract

Three key questions in relation to FMD vaccine usage are: (1) how soon can it confer protection, (2) how effective is it at preventing disease transmission , and (3) what is the likelihood that vaccinated animals could support local virus replication. Previous work funded under the MAFF Open Contract Scheme has shown that emergency foot-and-mouth disease vaccines, formulated with high potency antigens held by the International Vaccine Bank (IVB), can protect cattle, pigs and sheep within 4 days of immunisation. Assessments of efficacy have been based upon an indirect aerosol challenge, simulating airborne spread from an infected holding to a neighbouring farm. Recent events in the United Kingdom have shown how easily FMD virus can spread unnoticed in sheep flocks. This allowed wide geographical spread of the disease from infected to susceptible animals, via direct contacts at livestock distribution centres and markets. With respect to the likelihood of vaccinated and subsequently challenged animals excreting virus, most experimental work has so far been based on the study of conventional rather than high potency vaccines. The aims of this project will be to see how rapidly and effectively emergency (high potency) FMD vaccines can protect susceptible stock from direct contact virus challenge and to what extent they effect the kinetics and quantitative dynamics of virus replication and excretion, and thereby transmission. This project would also support a continuation of studies into the role of cytokines in early protection. The results of this project will guide modelling and policy development for a vaccine-based approach to the control of FMD.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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