Award details

Foot-and-mouth disease virus: the molecular basis of tissue tropism and persistence

Reference	BBS/E/I/00000958
Principal Investigator / Supervisor	Dr Terry Jackson
Co-Investigators / Co-Supervisors	Dr Haru - Hisa Takamatsu, Dr Geraldine Taylor
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	96,333
Status	Completed
Type	Institute Project
Start date	01/09/2002
End date	31/08/2005
Duration	36 months

Abstract

Foot-and-mouth disease virus (FMDV) causes a highly infectious, vesicular disease in cloven hoofed animals. In ruminants the acute phase is often followed by asymptomatic, persistent infection. This elusive infection also arises in vaccinated animals exposed to FMDV. The risk posed by such carrier animals is the crucial barrier to the use of vaccines in Europe for emergency disease control. In recent years we have learnt much about where the virus persists in carriers, and about mechanisms of host cell recognition in vitro. By linking and extending these two areas of research, this project aims to elucidate the molecular mechanisms underlying viral tropism and persistence in the natural host. This project, which combines molecular virology, immunology, and state-of-the-art histopathology, will provide vital intelligence in the war against FMD by revealing targets for therapeutic or immune intervention aimed at preventing, or curing, the carrier state.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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