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Role of lymphostatin in the colonisation of cattle by enterohaemorrhagic Escherichia coli

Reference	BBS/E/I/00000952
Principal Investigator / Supervisor	Dr Robert Somerville
Co-Investigators / Co-Supervisors	Dr Timothy Wallis
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	9,385
Status	Completed
Type	Institute Project
Start date	01/05/2002
End date	30/04/2005
Duration	36 months

Abstract

Enterohaemorrhagic E.coli (EHEC) are emerging zoonotic pathogens and cattle are a major reservoir of human infections. We have identified a gene (lifA) that influences intestinal colonisation of calves by non-O157 EHEC. LifA (lymphostatin) acts both as an inhibitor of lymphocyte function and as an adhesion in vitro. We aim to determine how lymphostatin influences intestinal colonisation through integration of genetic techniques and the in vitro and in vivo analysis of EHEC-interactions with bovine epithelial and lymphoid cells. The roles of an E.coli O157:H7 lifA homologue (17095) and truncated lifA gene will also be investigated. We will dissect the functional domains of lymphostatin to gain insights into its mechanism of action.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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