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A functional genomic approach to understanding the molecular pathogenesis of sheep scrapie
Reference
BBS/E/I/00000937
Principal Investigator / Supervisor
Professor Nora Hunter
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
63,285
Status
Completed
Type
Institute Project
Start date
01/10/2002
End date
30/09/2007
Duration
60 months
Abstract
This project will test the hypotheses that: 1) there are changes in relative levels of gene transcripts occurring in the CNS and FDC at specific times after scrapie infection in sheep; 2) TSE-induced changes to host cell gene expression are related to the clinical manifestation of scrapie disease; 3) the differential susceptibility of the distinct PrP genotypes to scrapie-induced disease is related to differential gene expression in the CNS and DFC. These hypotheses will be tested by microarray technology using a "non-redundant" bovine brain EST library augmented by genes from a sheep FDC cDNA library, from TSE infected animals. We will identify and quantify changes in CNS and FDC gene expression related to scrapie disease progression - in homozygous sensitive VRQ/VRQ, heterozygous VRQ/ARQ, and homozygous resistant ARR/ARR New Zealand cheviot sheep.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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