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Studies on the mechanisms of RSV vaccine enhanced disease in the bovine lung
Reference
BBS/E/I/00000925
Principal Investigator / Supervisor
Dr Geraldine Taylor
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
570,284
Status
Completed
Type
Institute Project
Start date
01/10/2001
End date
30/09/2004
Duration
36 months
Abstract
The lung represents an important interface between the environment and the immune system, and excessive or inappropriate immune responses in the respiratory tract can cause severe damage to the lungs. For example, certain inactivated human and bovine respiratory syncytial virus (RSV) vaccines have induced exacerbated respiratory disease following natural RSV infection. An understanding of the immune mechanisms underlying the balance between protection, disease and recovery from infection will aid the design of safe and effective RSV vaccines. The aims of this project are therefore to (i) experimentally reproduce vaccine-augmented respiratory disease in calves (ii) investigate the immune mechanisms contributing to vaccine-augmented disease (iii) compare such immune responses to those induced by live virus vaccines
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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