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Award details
Characterisation of the effects of salmonella induced intestinal inflammation on pathogenesis
Reference
BBS/E/I/00000923
Principal Investigator / Supervisor
Dr Timothy Wallis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
6,460
Status
Completed
Type
Institute Project
Start date
16/09/2001
End date
01/08/2004
Duration
35 months
Abstract
Our laboratory has identified several virulence factors that are involved in the induction of Salmonella-induced inflammation and shown that this is both host- and serotype-specific. Several unconnected studies have demonstrated that Salmonella modulation of pro-inflammatory cytokines can be both host- and serotype-dependent. In this proposal we aim to study Salmonella-induced intestinal inflammatory responses in the context of pathogenesis and host-specificity in a coordinated study using strains of defined virulence in pigs. Determining how Salmonella modulate intestinal inflammatory responses in the context of host specificity is potentially essential for understanding the pathogenesis of this complex zoonotic pathogen.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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