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Molecular aspects of integrin specificity of foot and mouth disease virus
Reference
BBS/E/I/00000910
Principal Investigator / Supervisor
Dr Terry Jackson
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
84,435
Status
Completed
Type
Institute Project
Start date
01/01/2002
End date
17/03/2005
Duration
39 months
Abstract
Foot-and-mouth disease virus (FMD), the highly infectious pathogen of cloven-hoofed animals, infects cells by attaching to integrin receptors through a conserved RGD tripeptide. Several integrins bind RGD ligands, but only one of these, alpha v beta 6, appears from our current research to be an efficient receptor for FMDV in nature. The choice is highly significant as alpha v beta 6 is expressed only in epithelial tissues, and normally only at low levels. We wish to determine how, in terms of sequence and structure, FMDV recognises alpha v beta 6. The work will further our understanding of the pathology of FMDV infections, both acute and persistent, and will underpin any future development of anti-FMDV agents based on receptor blockage.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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