Award details

The effect of age at challenge on subsequent development of BSE in sheep

Reference	BBS/E/I/00000899
Principal Investigator / Supervisor	Dr James Foster
Co-Investigators / Co-Supervisors	Professor Nora Hunter
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	22,127
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2007
Duration	72 months

Abstract

Previous studies involving the oral dosing of sheep with BSE (SE1424 and SE1428) have produced incubation periods in susceptible ARQ/ARQ sheep which so far have shown wide variation (553 to 1073 days), with a number of sheep surviving beyond 1200 days post-challenge. The fact that less than 100% of BSE infected sheep go on to develop clinical signs reduces the amount of information produced by each experiment. The purpose of this study is therefore (a) to establish whether the age at challenge has an effect on the incubation period of disease(b) to establish whether challenge at very young ages results in a higher percentage of animals developing clinical signs (c) to establish whether different dose rates affects disease incidence.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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