Award details

Identification and characterisation of chicken toll-like receptors

Reference	BBS/E/I/00000890
Principal Investigator / Supervisor	Dr Adrian Smith
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	36,718
Status	Completed
Type	Institute Project
Start date	01/12/2001
End date	13/08/2005
Duration	44 months

Abstract

Mammalian toll-like receptors (TLRs) are known to play an important role in the induction of the innate and adaptive immune responses and are associated with susceptibility to infectious disease. We aim to isolate chicken TLRs and to determine whether they are associated with genetic resistance to common poultry diseases using the IAH panel of inbred chicken lines which are known to differ in their resistance/susceptibility to a wide range of pathogens. Further, we will examine the role of selected TLRs in the chicken immune response by characterising the expression patterns of relevant tissues and cells before and after infectious challenge and by developing models to examine the specificity and function of individual TLR family members.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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