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Mechanisms of prion protein fragment neurotoxicity in organotypic slice cultures
Reference
BBS/E/I/00000885
Principal Investigator / Supervisor
Dr Janet Fraser
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
6,270
Status
Completed
Type
Institute Project
Start date
01/10/2001
End date
30/09/2004
Duration
36 months
Abstract
The aim of this project is to use organotypic hippocampal slice cultures and the mouse PrP 106-126 to develop an in vitro model of TSE induced neurodegeneration. Following exposure of the slices to PrP106-126 or control peptide, neurotoxicity mechanisms will be analysed by immunocytochemistry and Western blot. The project will allow the student to develop a variety of experimental techniques including organotypic slice tissue culture, immunocytochemistry, Western blotting and apoptotic assay. All the techniques are currently being used in this laboratory.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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