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Award details
Characterisation of Salmonella net growth in vivo and serotype host-specificity
Reference
BBS/E/I/00000860
Principal Investigator / Supervisor
Dr Timothy Wallis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
88,060
Status
Completed
Type
Institute Project
Start date
01/01/2001
End date
31/12/2003
Duration
36 months
Abstract
Bacterial net growth in vivo is essential for pathogenesis and is dependent on the rate of bacterial replication and bacterial resistance to killing by host defence mechanisms. Identifying the host specific nature of Salmonella net growth in vivo is the aim of this project. The net growth rates of S dublin, S choleraesuis and S gallinarum will be compared in calves and pigs by measuring the segregation of a temperature sensitive plasmid. The virulence gene loci of spv and Salomonella pathogenicity island 2 (SPI-2) have both been implicated in influencing net growth in vivo. Measuring the net growth rates in vivo of these serotypes carrying heterologous SPI-2 and spv loci will assess the role of these loci in influencing host specificity.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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