Award details

The glycoproteins of bovine viral diarrhoea virus

Reference	BBS/E/I/00000857
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	1,640
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2004
Duration	36 months

Abstract

Pestiviruses have three structural glycoproteins (Erns, E1 and E2). Both Erns and E2 bind to the surface of cells. Erns binds to cells through interactions with cell surface glycosylaminoglycans and E2 probably interacts with a specific receptor for the virus. Other functions of the glycoproteins, such as cell fusion activity, have yet to be assigned to a specific glycoprotein. The aims of the project are to define parameters of virus entry into cells: to describe any conformational changes in the glycoproteins that may take place during virus entry into cells; to examine the consequence of any change in conformation on the properties of the glycoproteins; and to investigate the route of virus entry into cells. It is hoped that a new way to purify virus from tissue culture will be developed which we hope will aid these analyses of the precise role of the virus glycoproteins in virus entry into cells.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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