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Does scrapie prevent BSE from replicating and producing disease in a single host? EXTENSION A386

Reference	BBS/E/I/00000853
Principal Investigator / Supervisor	Dr James Foster
Co-Investigators / Co-Supervisors	Professor Nora Hunter
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	134,065
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2007
Duration	72 months

Abstract

There is growing concern that BSE may have accidentally spread to sheep in the UK national flock and that the possibility of identifying suspect animals may be obscured if the host is already incubating natural scrapie. This study aims to establish whether it is possible to distinguish BSE and scrapie within a single host or whether the normally distinctive pathological and/or transmissible features of BSE become masked or altered when competing with other TSE sources - a phenomenon akin to strain blocking, which has been described in murine scrapie models. It could be, for example, that natural scrapie already incubating in sheep could prevent any subsequent BSE challenge from establishing an infection.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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