Award details

The potential and application of virus host evasion genes that modify apoptosis and cytokine responses

Reference	BBS/E/I/00000851
Principal Investigator / Supervisor	Dr Linda Dixon
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	82,190
Status	Completed
Type	Institute Project
Start date	01/12/2000
End date	30/11/2003
Duration	36 months

Abstract

The objectives of the project are: 1. Identification of NFkB and calcineurin binding sequences encoded within African swine fever virus gene A238L in order to develop corresponding peptoid analogues with clinical applications. 2. Finish/complete sequencing of complete Ectromelia virus (EV) genome. 3. Identification of novel viral modifiers of apoptosis, TNF and cytokine responses from the sequence of EV. 4. Identification of novel viral modifiers of apoptosis and TNF and cytokine responses through screening cloned viral ORFs and expression libraries of EV and mouse gamma-herpes virus 68 (MHV) 5. Identification of possible human homologues of novel viral modifiers of apoptosis, TNF and cytokine responses. 6. Identification of cellular targets of ASFV, EV and MHV modifiers of apoptosis, providing novel targets and strategies for development of drugs controlling cell proliferation. 7. Manipulation of apoptosis and TNF in vitro with virus by transgenic expression of virus host evasion genes, in order to provide new strategies for controlling immune responses in health and disease and to produce cell lines with improved growth characteristics for biotechnology. 8. Construction of virus deletion mutants as novel vectors for DNA delivery, protein expressions and vaccines. 9. Provide structural information on viral evasion molecules leading to design of new peptoid drugs for manipulation of immune responses

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search