Award details

Variations in immune responses determined by MHC class I polymorphism in cattle

Reference	BBS/E/I/00000828
Principal Investigator / Supervisor	Professor Shirley Ellis
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	63,710
Status	Completed
Type	Institute Project
Start date	02/10/2000
End date	01/10/2003
Duration	36 months

Abstract

Variation in the immune response due to MHC may be critical when considering vaccine design, particularly with regard to pathogens where immunodominance is shown to have a role. In Theileria parva infection of cattle, a 'heirarchy' is apparent in which certain MHC haplotypes/alleles are dominant in restricting T cell responses. T.parva therefore provides a model to study whether functionally dominant haplotypes/alleles have been selected in populations that have evolved with disease. This project has 2 aims: 1) To characterise the class I haplotypes that are dominant in restricting T.parva-specific T cell responses, 2) To determine the frequency of dominant alleles in cattle populations where the disease is present or absent, using PCR-SSP or DCSA, utilising existing data on cattle class I sequences. Such information may enable breeding strategies to be employed that will maximise the efficacy of vaccines currently under development.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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