Award details

Interaction of the capsid protein of Bovine Viral Diarrhoea virus with the virus genome and with cellular targets.

Reference	BBS/E/I/00000826
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	20,530
Status	Completed
Type	Institute Project
Start date	02/01/2001
End date	01/01/2004
Duration	36 months

Abstract

This project will address aspects of evasion of innate immunity by bovine viral diarrhoea virus (BVDV). It is known that BVDV infected cells seem to avoid cell death induced by Tumour Necrosis Factor (TNF). In the case of hepatitis C virus there are conflicting results with what virus polypeptide is responsible for this inhibition but the capsid protein has been reported to influence the intracellular TNF signalling pathway. It is hoped that the student will define how TNF signalling in BVDV infected cells is blocked and address which virus polypeptide is responsible for the inhibition through the use of TNF responsive reporter genes and virus polypeptide expression plasmids. If a candidate gene is found then its interaction with cellular signalling elements will be examined. It may also be possible to determine whether the strategy taken by the virus is to block of a single step or multiple steps in the induction innate antiviral immunity. Expression plasmids will be used to examine interactions of the capsid protein with virus RNA; in particular how it may interact with the terminal untranslated regions of the virus genome.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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