Award details

Investigation of macrophage responses to African swine fever virus infection using a porcine cDNA microarray

Reference	BBS/E/I/00000824
Principal Investigator / Supervisor	Dr Linda Dixon
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	81,050
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2004
Duration	36 months

Abstract

We are in a unique position to exploit array technology for investigating genome-wide changes in macrophage gene transcription in response to African swine fever virus infection. This technology will improve our understanding of the pathogenic mechanisms of ASFV. We will construct and use a porcine cDNA microarray to obtain expression profiles from uninfected macrophages; macrophages infected with ASFV isolates of varying pathogenicity; and macrophages infected with mutants lacking specific genes which interfere with host transcription factors. We will also examine macrophage responses to ASFV in warthogs and bushpigs, which can be infected but show no disease signs. This project will yield vital clues into virus immune evasion strategies, and provide a valuable insight into ASFV pathogenesis and natural host viral suppression mechanisms.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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