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Award details
Generation of MHC class I tetramers for measuring CTL responses to RSV in infected and immunised cattle
Reference
BBS/E/I/00000822
Principal Investigator / Supervisor
Professor Shirley Ellis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
14,860
Status
Completed
Type
Institute Project
Start date
01/04/2001
End date
31/03/2004
Duration
36 months
Abstract
The recently developed MHC class I tetramer technology will be adapted and optimised for use with cattle MHC class I genes. A number of characterised genes and peptides will be assessed during the first stage of the project. The resulting reagents will be used to quantitatively and qualitatively analyse T cell responses in cattle to respiratory syncytial virus, an important pathogen of young animals. This technique is unique in that it allows direct isolation of MHC and peptide-specific T cells from peripheral blood and tissues. It will be possible to study the kinetics, longevity and functional characteristics of antigen specific T cells following infection with RSV. In addition it will allow evaluation of vaccines under development.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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