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Award details
Investigation of determinants of host range & tissue tropism in morbilliviruses and the protein-protein interactions required for virus morphogenesis
Reference
BBS/E/I/00000820
Principal Investigator / Supervisor
Professor Thomas Barrett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
101,130
Status
Completed
Type
Institute Project
Start date
01/08/2000
End date
31/07/2002
Duration
24 months
Abstract
Though the chimeric virus has been tried as a potential vaccine, the detailed replication of such chimeric viruses in the natural hosts has not been studied so far. Therefore, in the proposed project the efficiency of growth of the chimeric viruses in cell culture will be studied in order to identify the different components of the virus, which are essential for efficient virus morphogenesis. Their tissue distribution in the normal hosts will also be studied and compared with those of the parent viruses. In order to study the infections in cell cultures and in tissues from infected/inoculated animals, different techniques like confocal microscopy, in situ hybridisation, electron microscopy with gold labelled specific antibodies, etc will be used.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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