Award details

Analysis of the function of Bovine Viral Diarrhoea Virus polypeptides

Reference	BBS/E/I/00000807
Principal Investigator / Supervisor	Dr John McCauley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	403,600
Status	Completed
Type	Institute Project
Start date	01/04/2000
End date	31/03/2003
Duration	36 months

Abstract

The aim of the programme is to determine the function of various virus polypeptides in the life cycle of BVDV. We are analysing the role of the 48kD glycoprotein (Erns) in virus binding to cells and how this activity is related to its ribonuclease activity. We are also examining how the NCP virus avoids the induction of interferon in cultured cells and we are examining which virus polypeptides are involved in this. It is noteworthy that CP strains of virus induce interferon and we plan to ask whether the induction of interferon is linked to cytopathogenicity. A molecular mechanism is not known for virus-cell fusion and we also hope to investigate which virus polypeptides are responsible for carrying out this activity.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search