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Interactions of Avian Influenza Viruses with the host cell
Reference
BBS/E/I/00000806
Principal Investigator / Supervisor
Dr John McCauley
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
310,689
Status
Completed
Type
Institute Project
Start date
01/04/2000
End date
31/03/2003
Duration
36 months
Abstract
The determinants of restricted replication of two HPAI viruses in mouse and human cells through the use of reverse genetics will be studied. From these experiments we hope to define regions of influenza virus polypeptides that are involved in interaction will cellular polypeptides. We also will examine replication of avian influenza viruses in early passage bovine cells to determine which influenza virus genes facilitate replication in these cells. We will determine if it is the same influenza virus gene that controls abortive infection of certain avian influenza viruses in human and mouse cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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