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Immunoglobulin diversification in immunosuppression induced by infectious bursal disease virus (IBDV).
Reference
BBS/E/I/00000805
Principal Investigator / Supervisor
Dr John Young
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
29,740
Status
Completed
Type
Institute Project
Start date
01/10/2000
End date
30/09/2003
Duration
36 months
Abstract
The initial aim of this project will be to examine the process of post-IBDV bursal recolonisation by analysis of the Ig gene sequences of the reconstituting population of B- cells in whole bursa and in individual follicles. PCR amplified Ig Vregions will be analysed by sequencing and the electrophoretic analysis of heteroduplexes with germline sequences. The data obtained will allow assessment of the oligoclonality of reconstituting cells, which will depend on their source. It will also reveal whether they are continuing Ig diversification by conversion, the extent of which will determine the effective capacity of the Ig repertoire available from the reconstituted follicles. There will be ample opportunity for the student to extend the studies to extrabursal sites to examine where and how IBDV-specific B- cells escape destruction, whether other activated cells escape and further studies of the reconstitution process.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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