Award details

Chicken costimulatory molecules

Reference	BBS/E/I/00000804
Principal Investigator / Supervisor	Dr John Young
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	21,270
Status	Completed
Type	Institute Project
Start date	01/07/2000
End date	30/06/2003
Duration	36 months

Abstract

Following our identification of CD28 in chickens, we have used it to clone the cDNA for the first avian member of the B7 family. The sequence of this molecule is more similar to LICOS than to CD80 or CD86, but unlike LICOS in mammals, it does bind chicken CD28 under physiological conditions. This leads to the hypothesis that there may be a different complement of B7 family molecules in chickens and mammals, with different sets of functions. The purpose of this project is to evaluate this hypothesis. This will involve detailed characterisation of the expression of the molecule in cells and tissues; evaluation of its capacity to provide costimulation signals and induce cytokine expression; identification of other molecules of both the B7 and CD28 families.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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