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Vaccine potential of EHV-1 antigens recognised by equine MHC class I restricted cytotoxic T lymphocytes
Reference
BBS/E/I/00000792
Principal Investigator / Supervisor
Professor Shirley Ellis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
95,850
Status
Completed
Type
Institute Project
Start date
01/10/2000
End date
30/09/2003
Duration
36 months
Abstract
EHV1 outbreaks cause significant financial loss to the Thoroughbred racehorse industry, and existing vaccines are not fully protective. We aim to establish the mechanism whereby EHV1 downregulates MHC class I expression on infected cells, and to identify viral proteins that are recognised by CTL. Using a variety of strategies, cloned MHC genes, and ponies expressing well-characterised MHC haplotypes, we aim to widen our understanding of the immune response to this virus. In this way we will be able to design improved vaccines.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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