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Award details
Cattle MHC class I: evolution and function
Reference
BBS/E/I/00000778
Principal Investigator / Supervisor
Professor Shirley Ellis
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
231,470
Status
Completed
Type
Institute Project
Start date
01/04/2000
End date
31/03/2003
Duration
36 months
Abstract
A primary objective is to elucidate the genetic basis underlying the observed phenotypic variation in MHC class I haplotypes, utilising the existing BAC library. A subsidiary aim is to identify and characterise genes encoding functionally related products such as TAP and NK receptors. The phylogenetic analyses of class I sequences will be continued in order to gain a better understanding of the evolution of cattle class I genes, and the relative roles of selection pressure and artificial breeding strategies on the maintenance of healthy populations. Information and reagents (e.g. class I transfectants) generated in this project will be used by other groups at IAH, and in externally funded projects within the MHC group. For example, class I-bound peptides derived from infected cells will be characterised and this information will be used to improve our understanding of immunity to specific pathogens.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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