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Award details
Generic coronavirus vectors for protection of farm animals against mucosal disease
Reference
BBS/E/I/00000746
Principal Investigator / Supervisor
Professor David Cavanagh
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
60,390
Status
Completed
Type
Institute Project
Start date
01/02/2000
End date
31/01/2003
Duration
36 months
Abstract
This project is aimed largely at rationally modifying the genomes of three coronaviruses, using recombinant DNA technology. One objective is to insert genes into a porcine and an avian coronavirus which will then act as vectors of the inserted genes for proteotype vaccine purposes. Strains will be genetically tagged by inserting identifiable foreign sequences. In addition, some of the discoveries will permit rational attenuation of coronaviruses, providing a new strategy for vaccine design. Furthermore, the results will provide great insights into the role of coronavirus genes in replication in general and pathogenicity in particular. Also, we shall shed light on a new emerging porcine disease (post-weaning multisystemic wasting symdrome) which is associated with porcine circovirus type (PCV) II. Genes of PCV type II will be incorporated into the porcine coronavirus vector.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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