Award details

Host cell invasion by Eimeria tenella: analyses of the molecular and genomic organisation of microneme-related genes

Reference	BBS/E/I/00000741
Principal Investigator / Supervisor	Professor Fiona Tomley
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	141,270
Status	Completed
Type	Institute Project
Start date	01/10/1998
End date	30/09/2001
Duration	36 months

Abstract

Host cell invasion by Eimeria tenella: analyses of the genomic organisation and regulation of microneme genes. The invasive life cycle stages of coccidial, protozoan parasites are characterised by an apical complex of organelles implicated in invasion of the host cell. One organelle, the microneme, from sporozoites of Eimeria tenella contains around eleven, typically acidic, proteins (mics), of which at least four possess regions or domains that belong to superfamilies of adhesive sequences found in a range of biologically significant molecules. In this project the expression and regulation of microneme proteins will be investigated, focussing initially on their ontogeny during formation of the sporozoite life cycle stage, the genomic organisation of representative mic genes and the isolation and characterisation of DNA sequences that may co-ordinately regulate their expression.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search