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Identification of cellular mRNAs translated in picornavirus- infected cells
Reference
BBS/E/I/00000727
Principal Investigator / Supervisor
Professor Graham Belsham
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
30,130
Status
Completed
Type
Institute Project
Start date
01/10/1999
End date
30/09/2002
Duration
36 months
Abstract
Isolation of ribosome-associated mRNAs from foot-and-mouth disease virus infected cells should permit the identification of specific mRNAs which are translated when cap-dependent protein synthesis is inhibited. This will be achieved by hybridisation of labelled probes derived from these mRNAs to pre-existing cDNA libraries. Some mRNAs with short unstructured 5' NCRs may be translated with little requirement for intact eIF4F. However, other mRNAs translated within the infected cells may contain cellular internal ribosome entry site (IRES) elements. The properties of such cellular IRES elements will be characterised and compared to the well known picornavirus IRES elements.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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