BBSRC Portfolio Analyser
Award details
Role of F-actin-binding by the influenza virus nucleoprotein
Reference
BBS/E/I/00000725
Principal Investigator / Supervisor
Dr John McCauley
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
14,230
Status
Completed
Type
Institute Project
Start date
01/10/1998
End date
30/09/2001
Duration
36 months
Abstract
This project is designed to investigate the interaction between influenza virus ribonucleoprotein complexes with elements of the cellular cytoskeleton and the plasma membrane of infected cells. The role of actin in the production of the filamentous form of influenza viruses will be examined through the use of drugs that affect actin polymerization and high-resolution atomic force microscopy will be used to investigate the nature of the budding of filamentous virus. Confocal microscopy will also be used to characterize the steps in virion assembly. Analysis of lipid rafts will also be done to determine their role in budding virus. Objectives: 1. To determine the role of actin in the production of the filamentous form of influenza viruses. 2. To determine the interaction between lipid-raft domains and cellular and virus components during virus assembly.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search