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Essential requirements for T cell responses in the immune animal
Reference
BBS/E/I/00000719
Principal Investigator / Supervisor
Dr Adrian Smith
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
175,560
Status
Completed
Type
Institute Project
Start date
01/10/1999
End date
30/09/2002
Duration
36 months
Abstract
The project is designed to examine the functional role for T cell subsets and effector mechanisms in mice rendered completely immune to E. vermiformis. To date, Isabelle has begun to define the capacity to transfer immunity with splenic cells from various gene knockout mice. The initial transfer experiments have defined a clear difference between protection against parasite replication, the induction of enteric pathology and the role of IFNg in this relationship. These studies are in their earliest stages but the strategies show considerable promise and should further define the important cell types and effector molecules in the immune animal.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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