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In ovo vaccination using infectious bronchitis defective RNAs expressing chicken cytokine and heterologous pathogen genes
Reference
BBS/E/I/00000718
Principal Investigator / Supervisor
Professor Peter Kaiser
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
44,030
Status
Completed
Type
Institute Project
Start date
01/10/1999
End date
30/09/2002
Duration
36 months
Abstract
The ability to genetically modify/manipulate viruses has led to their establishment as potential vectors for inducing protective immune responses against a variety of pathogens. Initially confined to DNA viruses, RNA viruses have now become attractive candidates for the expression of heterologous genes and offer promising opportunities for veterinary applications. Defective RNAs (D-RNAs) of the coronavirus Infectious Bronchitis Virus (IBV) can be utilised as RNA vectors for the expression of heterologous genes using a variety of helper IBV strains. The aim of this project is to develop this system for use in in ovo vaccination, and to investigate the efficacy of various chicken cytokines as vaccine adjuvants in this system.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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