Award details

Protein transport and membrane trafficking in picornavirus- infected cells

Reference	BBS/E/I/00000706
Principal Investigator / Supervisor	Professor Tom Wileman
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	26,840
Status	Completed
Type	Institute Project
Start date	01/11/1997
End date	31/10/2000
Duration	36 months

Abstract

It has been known for several years that large numbers of membrane vesicles are produced in cells infected with picornaviruses. These vesicles are essential for virus replication and their generation causes membrane transport between the endoplasmic reticulum and the Golgi apparatus to shut down. These results imply that picornavirus infection changes the careful balance of membrane budding and fusion that is normally maintained between ER and Golgi membrane compartments. Using Foot and Mouth Disease virus as a model system we plan to determine which viral proteins divert ER derived membrane vesicles into virus assembly sites, and determine at a biochemical and morphological level how and where they act.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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