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Award details
Reverse genetics for the production of antigenic and pathotypic variants of the coronavirus infectious bronchitis virus
Reference
BBS/E/I/00000702
Principal Investigator / Supervisor
Professor Paul Britton
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
16,930
Status
Completed
Type
Institute Project
Start date
01/04/1998
End date
31/03/2000
Duration
24 months
Abstract
Infectious bronchitis virus (IBV) is one of the most significant pathogens in the poultry industry. In spite of the use of vaccines diseases caused by variant IBV strains continue to result in great economic losses throughout the world. The objectives of the project are to use reverse genetics to produce antigenic and pathotypic variants of IBV to investigate the gene(s) involved in protective immunity and virulence. The ultimate aim is the ability to produce genetically modified vaccine strains capable of inducing immunological responses to protect against pathogenic variant IBVs. The IBV genome will be modified by using replicating defective RNAs (D-RNAs) for targeted recombination. Recombinant IBVs will be generated to investigate the gene(s) involved in virulence and immunogenicity.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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