Award details

Oral TSE pathogenesis: identification of neuroanatomical pathways and interaction with lymphoid tissue

Reference	BBS/E/I/00000678
Principal Investigator / Supervisor	Mrs Patricia McBride
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	31,110
Status	Completed
Type	Institute Project
Start date	01/04/1999
End date	01/04/2002
Duration	36 months

Abstract

The oral route of infection is the most relevant pathway for natural transmission of TSEs. However, the mechanisms involved are poorly understood and a better understanding is vital to intervention and prevention. The lymphoreticular and peripheral nervous systems are involved in the the early stages of pathogenesis. The spleen and other lymphoid tissues harbour infectivity soon after infection and this is subsequently targeted to sites in the CNS via the PNS but the interaction between the two systems is unknown. This project aims to use a mouse model of scrapie to identify the neuroanatomical pathways and timing of events involved in the spread of infection from the gut through the LRS and peripheral NS to the CNS: specifically, we intend to identify the early target sites in which abnormal PrP and infectivity accumulate. We also plan to orally-infect mouse models in which either the immune or sympathetic nervous systems are funtionally deficient in order to separate the individual roles of these systems in the spread of infection.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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