Award details

Scrapie strain influences on the cellular targeting of infection in the peripheral lymphoid system

ReferenceBBS/E/I/00000677
Principal Investigator / Supervisor Dr Moira Bruce
Co-Investigators /
Co-Supervisors
Institution The Pirbright Institute
DepartmentThe Pirbright Institute Department
Funding typeResearch
Value (£) 66,520
StatusCompleted
TypeInstitute Project
Start date 17/08/1999
End date 17/08/2002
Duration36 months

Abstract

Our recent studies of the ME7 mouse scrapie strain indicate that follicular dendritic cells (FDCs) of the spleen produce PrP, support replication and are critical for neuroinvasion. In contrast, studies elsewhere have implicated B cells in replication and neuroinvasion after challenge of mice with the RML scrapie isolate. We will test the hypothesis that different scrapie strains target different cell types of the immune system. Knockout mice lacking specific cells of the immune system will be challenged with different scrapie strains, to determine their susceptibility and whether infectivity can replicate in their spleens. We will also determine the cellular and subcellular location of PrP within the spleen in mice infected with a range of scrapie strains.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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