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Scrapie strain influences on the cellular targeting of infection in the peripheral lymphoid system
Reference
BBS/E/I/00000677
Principal Investigator / Supervisor
Dr Moira Bruce
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
66,520
Status
Completed
Type
Institute Project
Start date
17/08/1999
End date
17/08/2002
Duration
36 months
Abstract
Our recent studies of the ME7 mouse scrapie strain indicate that follicular dendritic cells (FDCs) of the spleen produce PrP, support replication and are critical for neuroinvasion. In contrast, studies elsewhere have implicated B cells in replication and neuroinvasion after challenge of mice with the RML scrapie isolate. We will test the hypothesis that different scrapie strains target different cell types of the immune system. Knockout mice lacking specific cells of the immune system will be challenged with different scrapie strains, to determine their susceptibility and whether infectivity can replicate in their spleens. We will also determine the cellular and subcellular location of PrP within the spleen in mice infected with a range of scrapie strains.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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