Award details

Improving prospects for scrapie control in sheep and goats by study of host geotype, TSE isolates and their in vivo and in vitro interaction

Reference	BBS/E/I/00000668
Principal Investigator / Supervisor	Professor Nora Hunter
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	9,600
Status	Completed
Type	Institute Project
Start date	01/01/1998
End date	30/06/2001
Duration	42 months

Abstract

The objectives of this project are firstly to create a network of sheep PrP geneticists throughout Europe and to carry out genotyping at the three most important PrP codons in sheep from different countries and breeds to those which have been tested previously. In order to underpin this effort, improved genotyping techniques will be developed. Strain typing transmission studies (to mice)will be set up from several outbreaks of scrapie in different countries and comparisons made with previous transmissions using scrapie and BSE. In addition PrPSC biochemical strain typing methods will be improved and differences in brain areas damaged by disease will be assessed. The potential for sheep to act as carriers of infection will be investigated using similar techniques. Sheep deviating from the expected response to scrapie will be investigated for any influence of other PrP gene polymorphic variants and genes other than the PrP gene in disease incidence (for example the sheep MHC or OLA genes). The extended number of sheep flocks which this partnership will make available will greatly shorten the time necessary to confirm and extend any new information generated and to develop breeding strategies for the control of scrapie in Europe.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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