Award details

Bioassay of infectivity from patients with CJD

Reference	BBS/E/I/00000663
Principal Investigator / Supervisor	Dr Moira Bruce
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	56,720
Status	Completed
Type	Institute Project
Start date	30/11/1997
End date	31/03/2001
Duration	40 months

Abstract

Our recent studies have established that both new variant CJD (nvCJD) and sporadic CJD (spCJD) are transmissible to mice, by injection of high concentrations of brain homogenates. Mouse transmissions are now being used to assess levels of infectivity in spleen, buffy coat and plasma from patients with nvCJD and spCJD. Infectivity in brain and spleen from nvCJD and spCJD patients are also being titrated to establish the limits of sensitivity of the mouse bioassay and to compare the sensitivities of bioassay and the biochemical detection of protease resistant PrP (PrPres), which is regarded as a marker for TSE infection.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search