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Award details
Development of high throughput screening methods for anti-prion therapeutic agents
Reference
BBS/E/I/00000656
Principal Investigator / Supervisor
Dr James Hope
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
242,766
Status
Completed
Type
Institute Project
Start date
02/10/1997
End date
01/10/2000
Duration
36 months
Abstract
Drug development often entails screening many thousands (or millions) of compounds and, in a competitive pharmaceutical environment, useful screens must operate at a rate of one or two compounds per minute. Current in vitro conversion systems for studying the inhibition of conversion of PrPC to PrPSc are very useful for low-throughput screening of potential TSE prophylactic compounds prior to in vivo evaluation (see 117/648). However, they use high levels of potentially-hazardous radioactive 35S and take one or two days to complete. In proof-of-principle experiments, we are adapting the in vitro conversion assay to a non-radioactive, microtitre plate format more suitable for high- throughput screening .
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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