Award details

BSE agent replication in bovine brain cell lines

Reference	BBS/E/I/00000649
Principal Investigator / Supervisor	Professor Nora Hunter
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	2,414
Status	Completed
Type	Institute Project
Start date	01/11/1997
End date	31/10/2000
Duration	36 months

Abstract

The main objectives (in collaboration between Moredun and NPU) is to determine by bioassay in mice whether the BSE pathogen/infectious agent replicates in bovine brain cell lines in culture. Evidence of replication would confirm that bovine brain cell lines provide an authentic and economical model for BSE-infected cattle. Persistently infective bovine brain cell lines would be of considerable value in further investigation of BSE pathogenesis in a controlled environment. Testing of drugs or metabolites which stop further spread of the agent would provide information on the mechanisms of entry into or exit from brain cells and this knowledge could be beneficial for treatment of CD.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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