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Award details
Design and synthesis of potential chemotherapeutic agents for the treatment of transmissible spongiform encephalopathies
Reference
BBS/E/I/00000648
Principal Investigator / Supervisor
Dr James Hope
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
32,946
Status
Completed
Type
Institute Project
Start date
02/10/1997
End date
01/10/2000
Duration
36 months
Abstract
Sulphated aromatic dyes such as Congo red inhibit replication of TSE agents and the accumulation of PrPSc in scrapie-infected cell cultures. These dyes have poor cellular uptake, bind to many other molecules and, in some cases, are highly cytotoxic and carcinogenic in vivo. We aim to identify the structural features of these dyes which makes them effective against prions in vitro and then to improve their pharmaceutical profiles several cellular permeability, bioavailability, toxicity and selectivity several by chemical modification. Series of structural analogues of Congo Red have been synthesised and we are currently measuring their ED50 values for the inhibition of conversion of PrPC to PrPSc in vitro and in the IAH scrapie- infected SMB cell line.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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