Award details

Identification and mapping of BSE susceptibility genes in the mouse and human

Reference	BBS/E/I/00000638
Principal Investigator / Supervisor	Dr Moira Bruce
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	244,614
Status	Completed
Type	Institute Project
Start date	01/09/1997
End date	31/03/2003
Duration	67 months

Abstract

The mouse strains RIII and C57BL differ by 100 days in their incubation periods following infection with BSE directly from cattle. The mouse strains have the same PrP type, suggesting that genes other than that encoding PrP influence pathogenesis in this cross-species transmission. The design of this project is to set up a backcross between the RIII and C57BL strains and to infect each offspring with BSE. The incubation period of each individual is being determined and, using interval mapping, quantitative trait loci (QTL) influencing incubation period are being localised. Comparison of the gene maps of mouse and human will indicate where homologous QTLs are located in the human genome and will indicate possible candidate genes corresponding to the QTLs.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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