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Award details
Bacteriophage display antibodies recognising PrP
Reference
BBS/E/I/00000636
Principal Investigator / Supervisor
Dr John Young
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
52,583
Status
Completed
Type
Institute Project
Start date
01/09/1997
End date
25/02/2001
Duration
42 months
Abstract
The pathology of transmissible spongiform encephalopathies involves accumulation of an altered form of the protein PrP. TSEs are thus diseases of protein conformation and processing, and it is important to have reagents that distinguish different forms of the protein. The aim of this project is to make such reagents using bacteriophage display antibody libraries. Phage-display antibodies have been produced from libraries from chickens immunised with recombinant PrP and from libraries of human phage antibodies. Both recombinant PrP and peptide arrays have been used for selection. These reagents are currently being evaluated for use in structural and cell biology of PrP.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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